亚低温冬眠疗法联合纳洛酮治疗弥漫性轴索损伤的分析

目的探讨弥漫性轴索损伤(DAI)亚低温冬眠疗法联合纳洛酮治疗的临床疗效。方法 2004年1月～2009年1月我院收治DAI患者82例,40例采用亚低温冬眠疗法联合纳洛酮疗法,42例采用常规治疗方法,治疗效果以平均昏迷持续时间、3个月随访病死率,6个月随访GOS评分进行评价。结果本组82例,亚低温冬眠疗法联合纳洛酮治疗,能够缩短DAI患者昏迷时间,降低患者病死率,改善患者远期神经功能恢复情况。结论本组患者通过早期应用亚低温联合纳洛酮疗法,可以提高DAI的治疗效果。

Objective To observe the therapeutic efficacy of mild hypothermia combined with naloxone on diffuse axonal injury （DAI）. Methods The data of 82 patients with DAI from January 2004 to January 2009,40 patients were treated by mild hypothermia combined with naloxone,42 patients were treated by regular methods, the effect of the therapy can be evaluated by the average duration of coma,the mortality of 3 months follow-up and the GOS of the 6 months follow up. Results 82 patients in this group, the therapy of mild hypothermia combined with naloxone ,can decrease the duration of coma,decrease the mortality ,improve the recovery of neurological function on DAI. Conclusion The early therapy of mild hypothermia combined with naloxone can improve the therapeutic efficacy on DAI.