儿童下丘脑错构瘤的治疗探讨

Options and Prognosis in Treatment of Hypothalamic Hamartoma

下丘脑错构瘤多见于儿童的先天性脑发育异常,以痴笑样癫癎、性早熟及认知行为障碍为主要症状特点。近年来的研究表明,通过手术或内镜的方法对下丘脑错构瘤进行切除和(或)离断术有比较确切的疗效,本文试图从策略和方法两个方面探讨下丘脑错构瘤的治疗新理念。

Hypothalamic hamartomas mostly present in childhood are rare congenital malformations with the usual presentation of gelastic seizure, precocious puberty and/or development delay. The relative roles of surgical resection, endoscopy and radiosurgery in the management of patients with such lesions have remained controversial. All the literature about treatment and prognosis in the past ten years were reviewed. Resection or disconnection of hypothalamic hamartomas via surgical and/or endoscopy approaches were found have efficacy in the treatment. The clinical outcomes and treatment options including surgery, endoscopy and radiosurgery were discussed.