ω-3多不饱和脂肪酸治疗急性肺损伤的疗效观察

The effect of ω-3 polyunsaturated fatty acid on acute lung injury

目的探讨ω-3多不饱和脂肪酸对急性肺损伤(ALI)疗效。方法选择ALI患者39例,随机分为2组。对照组(19例)予以常规治疗,治疗组20例在常规治疗基础上加用ω-3多不饱和脂肪酸。对比2组治疗有效率及治疗后2、4和8 d的血气分析变化观察氧分压、氧合指数等的变化。结果治疗组有效率为70%,与对照组31.6%相比差异有统计学意义(P<0.05);治疗组PaO2、氧合指数高于对照组,同时心率、乳酸水平,下降较对照组明显,差异有统计学意义(P<0.05),特别是乳酸(P<0.01)。结论ω-3多不饱和脂肪酸应用有助于改善ALI患者的呼吸功能及预后。

Objective To investigate the effect ofω-3 polyunsaturated fatty acid on acute lung injury.Method Analysis was performed on 39 patients who were divided into two groups,control group（19） and therapeutic group（20）.The 19 patients in control group were given conventional treatment,while the other 20 patients in therapeutic group were given ω-3 polyunsaturated fatty acid based on the conventional treatment.The efficacies as well as the heart rates,PaO2,PaO2 /FiO2,blood lactates and CRP of the two groups were analyzed.Result The effective rate was 70% in therapeutic group and 31.6% in control group.There was significant difference between the two groups.The heart rates,PaO2,PaO2 /FiO2,blood lactate and CRP of therapeutic group were significantly higher than those of control group（P 0.05）,especially CRP（P 0.01）.Conclusion ω-3 polyunsaturated fatty acid can improve the outcome of ALI.ω-3 polyunsaturated fatty acid can improve the outcome of ALI.