大鼠脑复苏过程中血浆皮质醇含量变化与早期神经功能评分的关系

The relevance between plasma cortisol concentrations and early neurological function scores in rats during cerebral resuscitation

目的 探讨脑复苏过程中大鼠血浆皮质醇含量与早期脑复苏效果的相关性.方法 采用经食管电击法建立室颤性（VF）心脏骤停模型,放射免疫法测定血浆皮质醇含量,改良的神经功能缺陷评分（NDS）法测定神经功能的早期恢复情况.结果模型组大鼠心肺复苏成功后10 h的血浆皮质醇含量高于假手术组（P〈0.05）,而其NDS评分结果却低于假手术组（P〈0.05）;在模型组中,大鼠血浆皮质醇含量与NDS评分结果呈线性负相关（r=-0.69,P〈0.05）.结论 心肺复苏成功后神经功能的早期恢复程度与血浆皮质醇含量呈线性负相关.

Objective To explore the relevance between plasma cortisol concentrations and early neurological function scores in rats during cerebral resuscitation. Methods Ventricular fibrillation （VF） cardiac arrest model in rat was reproduced by transesophageal electric shock method, the plasma cortisol was determined by the radioimmunoassay method, the early recovery of neurological function was determined by the improved neurological deficit score （NDS）. Results Plasma cortisol concentrations were higher in The model group than that in sham - operated group （ P 〈 0. 05 ） ; but the NDS were lower in the model group than that in sham - operated group （ P 〈 0. 05 ） ; the plasma cortisol concentrations were linear negative correlated with NDS in the model group （ r = - 0. 69, P 〈 0. 05 ）. Conclusion The early recovery of neurological function is linear negative correlated with plasma cortisol concentrations after eardiopulmonary resuscitation.