有皮肤结节表现的继发性甲状腺功能减退

Cutaneous nodules caused by secondary hypothyroidism

报告1例甲状腺功能减退所致的小腿皮肤结节性损害。患者女,57岁。双小腿出现结节约1年余,无痛、有轻度瘙痒,曾有甲状腺功能亢进病史,因服抗甲状腺药物过敏,采用同位素碘(^(131)I)口服治疗,但在小腿部、双眼上睑等逐步发生多发性皮肤结节,通过皮损组织病理检查、甲状腺扫描、甲状腺吸碘率、血清甲状腺系列检测后诊断为继发甲状腺功能减退引起的黏液性水肿。经给予甲状腺素治疗后患者的双下肢皮肤结节、斑块逐渐缩小直至基本消失。

To report a case of cutaneous nodules on shanks and its differential diagnosis. The patient was female, 57 years old. The nodules on the shanks appeared for more than one year with no feeling of pain, but mild gargalesthesia. Because of allergy to antithyreid drug, the patient had history of hyperthyroidism and was treated with oral isotope of ^131I. And nodules gradually appeared on shanks and both of the upper eyelids. Depending on results of biopsy and histopathological examination of the lesion, nuclear medicine thyroid scanning, examination of thyroid iodine uptake and serum thyroid series, it was diagnosed as myxedema. After giving thyroxine, her cutaneous nodules on the shanks grew down gradually to almost disappeared.