叉头状转录因子3和转化生长因子-β1在口腔扁平苔藓中的表达及意义

Expression and significance of forkhead box P3 and transforming growth factor-β1 in oral lichen planus

目的:研究叉头状转录因子3(Foxp3)和转化生长因子β1(TGF-β1)在口腔扁平苔藓(OLP)组织中的表达及意义。方法:采用免疫组织化学法检测15例正常口腔黏膜(NOM)组织(NOM组)、30例OLP组织中的Foxp3和TGF-β1表达。结果:Foxp3在NOM组阴性表达,在OLP组表达强度及表达率均显著高于NOM组(P<0.01);TGF-β1在NOM组弱阳性表达,在OLP组表达强度显著高于NOM组(P<0.01),表达率与NOM组无区别(P>0.05);在OLP组Foxp3和TGF-β1表达无相关性(P>0.05)。结论:Foxp3和TGF-β1参与了口腔扁平苔藓的发病。

Objective To investigate the expression and significance of forkhead box P3 （Foxp3） and transforming growth faetor-β1（TGF-β1） in oral lichen planus （OLP）. Methods The expressions of Foxp3 in 15 normal oral mucosa（NOM） tissues and TGF-β1 in 30 OLP tissues were detected by immunohistochemieal experiment. Results The expression of Foxp3 was negative in the NOM, the expression intensity and rate of Foxp3 in the OLP was significantly higher than that in the NOM （P 〈 0.01 ） ; Weak expression of TGF-β1 was noted in the NOM, the expression intensity of TGF-β1 in the OLP was significantly higher than that in the NOM （P 〈 0.01）,but the expression rate had no significant difference between the NOM and the OLP （P 〉 0.05） ; The expression of Foxp3 and TGF-β1 in the OLP had no obvious correlation （P 〉 0.05）. Conclusion Foxp3 and TGF-β1 involved in the pathogenesis of oral lichen planus.