鼻咽癌治疗后颈转移灶残留或复发的再治疗

Re-treatment of residual/recurrent cervical metastasis after radiotherapy for nasopharyngeal carcinoma

目的探索一种适合鼻咽癌首程治疗后颈淋巴结残留或复发的再治疗方案,为这类患者的临床治疗提供参考。方法总结46例鼻咽癌患者首程治疗后颈淋巴结残留或复发的再治疗资料,将不同的治疗方案与疗效之间的关系应用统计学进行分层分析。结果 46例患者5年生存率为59%。手术再治疗组术后5年生存率为72%,放、化疗组再治疗后5年生存率为26%,差异有显著的统计学意义。结论鼻咽癌首程治疗后颈淋巴结残留或复发的再治疗,手术是首选的治疗方式,能显著提高生存率。

OBJECTIVE To explore a suitable retreatment for residual/recurrent cervical metastasis after initial therapy of nasopharyngeal carcinoma,and provide a clinical treatment strategy for these patients. METHODS The clinical data of 46 NPC cases with residual/recurrent cervical metastasis after initial therapy were studied,and their relationship between different regimens and therapeutic effect was analyzed by using stratified analysis method. RESULTS The 5-year survival rate of 46 patients was 59%. The 5-year survival rates in surgical group and radio-chemotherapy group were 72% and 26% respectively. There were significant difference between the two groups（P〈0.05）. CONCLUSION Surgery is the preferred treatment of residual/recurrent cervical metastasis after initial treatment for nasopharyngeal carcinoma,and it can significantly improve the survival rate.