摘要
流感嗜血杆菌（Haemophilus influenzae,Hi）蛋白D（Protein D,PD）是高度保守的表面脂蛋白,相对分子质量42 000,存在于所有的可分型Hi和不可分型Hi（nontypeable Haemophilus influenzae,NTHi）中,是一种具有甘油磷酸二酯酶活性的细菌毒力因子,能导致宿主上皮细胞释放磷酸胆碱,在Hi引起呼吸道感染过程中起重要作用.以NTHi PD作为载体蛋白的肺炎链球菌多糖结合疫苗,不但能预防肺炎链球菌性耳炎,而且对NTHi引起的急性中耳炎也具有预防作用.PD是迄今为止第一种能在人类机体中诱导保护性应答的NTHi抗原,也是最具潜力的多糖结合疫苗候选载体蛋白.
Protein D （PD） is a highly conserved surface lipoprotein（M, 42 000） found in all Hae mophilus influenzae （Hi）, including nontypeable Haemophilus influenzae （NTHi）.PD is a virulence factor with glycerophosphodiesterase activity, which can lead to the release of phosphorylcholine from host epithelial cells, and plays an important role in the pathogenesis of respiratory tract infection caused by Hi.Pneumococcal polysaccharide conjugate vaccine using NTHi PD as a carrier protein can protect against acute otitis media caused by both pneumococci and NTHi.PD is not only a potential carrier protein candidate for polysaccharide conjugate vaccines but also the first NTHi antigen which can induce protective response in human.
出处
《国际生物制品学杂志》
CAS
2010年第4期205-208,共4页
International Journal of Biologicals
关键词
嗜血菌
流感
载体蛋白质类
抗原
蛋白D
Haemophilus influenzae
Carrier proteins
Antigens
Protein D
