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CRTH2受体与变态反应中炎症细胞关系的研究进展

Progress of CRTH2 receptor and inflammatory cells in allergic reaction
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摘要 PGD2/CRTH2在变态反应性疾病过程中发挥重要的作用,研究表明CRTH2在过敏性炎症的发生和发展过程中,其所传导的信号可以介导Th2细胞、嗜酸粒细胞和嗜碱粒细胞等炎症细胞的趋化和炎症介质的释放.目前有关CRTH2的基础性研究国内报道的较少,本文就CRTH2受体与变态反应中炎症细胞关系的研究进展作一综述,通过对其深入研究,为变态反应性疾病的防治提供新的靶点. The prostagland in D2/chemoattractant receptor-homologous molecule expressed on Th2 cells （PGD2/CRTH2） signal pathway plays an importance role in allergic diseases, various studies show that the CRTH2 signal can stimulates cytokine production and migration in Th2 cells, eosinophils and basophils. In the review, we discuss the relation between CRTH2 and allergic cells, we hope that a new target can be found for the prevention and treatment of allergic diseases.
作者 陶金好 孔完明 曹兰芳
机构地区 上海交通大学医学院附属仁济医院儿科
出处 《国际呼吸杂志》 2010年第15期948-950,共3页 International Journal of Respiration
基金 上海市科委基金资助项目（064107048）
关键词 CRTH2受体 TH2细胞 嗜酸粒细胞 嗜碱粒细胞 上皮细胞 Chemoattractant receptor-homologous molecule expressed on Th2 cells Th2 cells Eosinophils Basophils Epithelial cells
分类号 R593.2 [医药卫生—内科学]
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参考文献22

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国际呼吸杂志
2010年 第15期

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