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Apelin—APJ系统在心肺血管疾病中的研究进展

Apelin-APJ system in heart and lung disease in progress
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摘要 血管紧张素受体相关的受体蛋白（Apelin）是G蛋白耦联受体APJ的内源性配体.Apelin和APJ存在于大鼠及人体内,多个器官、组织均有其分布,且于心肺组织含量最高,具有增强心肌收缩力、舒张血管、降低血压等作用.其作用可能通过扩张血管、拮抗血管紧张素Ⅱ、一氧化氮机制等.Apelin有可能成为治疗心肺血管疾病的新靶点. Apelin is the coupled receptor of G protein APJ. Apelin and APJ are distributed in many tissues and organs of human and rats,the most in heart and lung. They have many effects on many organs. Apelin may enhanced myocardial contractility and diastolic blood vessels,decrease blood pressure,and its mechanism includes dilating vessels, antagonizing Ang Ⅱ and nitric oxide-dependent mechanism. Apelin may make it a novel drug target of therapeutic applications in the heart and pulmonary diseases.
作者 刘燕 袁雅冬
机构地区 河北医科大学第二医院呼吸内科
出处 《国际呼吸杂志》 2010年第15期951-955,共5页 International Journal of Respiration
关键词 血管紧张素受体相关的受体蛋白 APJ 心血管 肺 Apelin APJ Cardiovascular Lung
分类号 R54 [医药卫生—心血管疾病]
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参考文献28

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二级参考文献26

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国际呼吸杂志
2010年 第15期

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