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慢性移植物抗宿主病的临床表现及诊断

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摘要 异基因造血干细胞移植(Allo-HSCT)是当前治疗各种恶性血液病的最重要的方式之一,随着HLA不相合同胞和无关供者外周血干细胞移植在临床中的广泛应用,临床病例不断增加,慢性移植物抗宿主病(graft-versus-host disease,GVHD)已成为影响移植后患者长期生存率和生活质量的主要原因.慢性GVHD是一种多系统的慢性同种免疫和自身免疫疾病,其特点是免疫受抑,免疫失调,脏器功能不全,尽管美国国立卫生研究院共识发展项目建议的临床试验标准已经开始对慢性GVHD进行规范的诊断和临床评估,但国际上对于慢性GVHD的临床表现、诊断、分级及生物学标记仍缺乏统一的认识,因此对慢性GVHD做出及时而准确的临床诊断及分级评估至关重要.
出处 《国际输血及血液学杂志》 CAS 2010年第4期315-318,共4页 International Journal of Blood Transfusion and Hematology
基金 基金项目:广东省科技计划项目项目编号:2009A030200007
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