M蛋白对诊断多发性骨髓瘤的临床应用价值

The Clinical Value of M protein on the Diagnosis of Multiple Myeloma

目的:探讨M蛋白对诊断多发性骨髓瘤(multiplemyeloma,MM)的临床应用价值。方法:对184例确诊为多发性骨髓瘤(MM)患者的免疫球蛋白定量、本周蛋白的检测以及免疫固定电泳的检测结果进行综合分析。结果:在184例MM患者中,以中年人和老年人(137人)多见,50岁以下(47人)少见,男性明显多于女生(127:57);免疫球蛋白分型IgG所占比例最大(47.46),IgE最小(0.56%);IgG、IgA和IgM型患者对应的Ig的血清平均浓度均显著增高;无论是Kappa型MM患者还是Lambda型MM患者,Kappa/Lambda比值与非MM患者均有显著性差异。结论:应用免疫固定电泳、本周蛋白的检验及免疫球蛋白定量等方法可以更敏感地检测出M蛋白,并对其分类、分型,为临床多发性骨髓瘤的诊断和治疗提供重要依据。

Objective：To study the clinical value of M protein on the diagnosis of multiple myeloma（MM）.Methods：Analysis the results of serum protein electrophoresis,immunoglobulin quantification,detection of Bence-Jones protein and immunofixation electrophoresis on 184 patients diagnosed with multiple myeloma.Results：In 184 cases of MM patients,middle-aged and old persons（137）are more than those under the age of 50（47）,men more than women（127：57）;Coming to immunoglobulin type,IgG accounts for the largest proportion（47.46%）,IgE the lowest（0.56%）;the average seral concentration of immunoglobulin protein with the corresponding IgG,IgA and IgM type patients increased significantly;Compared with non-MM patients,both Kappa-MM patients and Lambda-MM patients have significant differences.Conclusion：The application of immunofixation electrophoresis,detection of Bence-Jones protein and immunoglobulin quantitative methods can more sensitively detect the M protein,define its classification and type,and provide significant evidence for diagnosis and treatment of clinical multiple myeloma.