组织蛋白酶-D和MMP-9在非小细胞肺癌中的表达意义

Expression and significance of cathepsin-D and MMP-9 in non-small cell lung carcinonma( NSCLC)

目的检测组织蛋白酶-D(Cath-D)和基质金属蛋白酶-9(MMP-9)在非小细胞肺癌中的表达,探讨Cath-D和MMP-9在非小细胞肺癌发生发展及转移中的作用。方法应用免疫组织化学法检测96例非小细胞肺癌组织及60例正常肺组织中Cath-D和MMP-9的表达情况,并将检测结果与临床病理特征进行综合分析。结果 Cath-D和MMP-9的表达主要定位于细胞质,Cath-D和MMP-9在非小细胞肺癌中表达的阳性率明显高于正常肺组织。非小细胞肺癌中Cath-D和MMP-9蛋白的表达与有无胸膜侵犯和淋巴结转移情况密切相关。结论 Cath-D和MMP-9在非小细胞肺癌中表达上调,联合检测Cath-D和MMP-9可能对判断肿瘤的预后有重要价值。

Objective To detect the expressions of cathepsin D（ Cath-D） and MMP-9,and investigate their significance on development and metastasis in non-small cell lung carcinonma（ NSCLC） . Methods The study included 96 cases of NSCLC as experimental group and 60 cases of normal lung tissues as control group. We detected the expressions of Cath-D and MMP-9 in different clinical and pathological characters by using IHC. Results The positive rate of Cath-D and MMP-9 were higher in the experimental group than in control group. Comparisons of the control group,the positive rate of Cath-D and MMP-9 were correlated with pleural invasion and lymph node metastasis. Conclusion The high-expressions of Cath-D and MMP-9 may promote the occurrence and development in NSCLC. The joint detection of Cath-D and MMP-9 should be helpful to predict the prognosis in NSCLC.