期刊文献+

乳腺癌组织中VEGF的表达及临床意义 被引量:1

下载PDF
导出
摘要 目的:探讨乳腺癌组织中血管内皮生长因子(VEGF)的表达及其临床病理意义。方法:采用快捷免疫组化MaxVisionTM法,对68例乳腺癌组织和22例乳腺良性病变组织中VEGF的表达进行检测,结合临床及病理形态学资料进行统计分析。结果:VEGF的阳性表达率为乳腺癌42.6,乳腺良性病变组织中为5.02,两者比较,差异均有统计学意义(均P〈0.05)。VEGF的表达与乳腺癌患者年龄、肿瘤大小及组织学分型无关,而与乳腺癌组织学分级、临床分期和腋窝淋巴结转移有关(P〈0.05)。结论:VEGF可能与乳腺癌的进展、转移及预后有关,作为独立的指标对判定预后和制定治疗方案具有参考意义。
作者 张明彩
出处 《医学信息(医药版)》 2008年第10期63-65,共3页
  • 相关文献

同被引文献10

  • 1Parkin DM, Bray F, Ferlay J, et al. Estimating the world cancer burden: Globocan 2000 [ J ]. Int J cancer, 2001,94 (2) :153 - 155.
  • 2Bauer KR, Brown M, Cress B.D, et al. Descriptive analysis d estrogen receptor ( ER )-negative, progesterone receptor (PB)-negative,and HEB2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry[J]. Cancer,2007, 109(9) :1 721 -1 728.
  • 3Haffty BG,Yang Q,Reiss M,et al. Locovegional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer [ J ]. J Clin Oncol, 2006,24 (36) : 5 652 -5 657.
  • 4Dent R, Trudeau M, Pritchard KI, et al. Triple-negative breast cancer:cllnical features and patterns of recurrence [J]. Clin Cancer Res,2007,13(15 Ptl) :4 429 -4 434.
  • 5Cleator S, HeUer W, Coombes RC. Triple-negative breast cancer: therapeutic options[ J ]. Lancet Oncol,2007,8 (3) : 235 - 244.
  • 6Rakha EA,EI-Sayed ME,Green AR,et al. Prognostic mark- ers in triple-negative breast cancer [ J ]. Cancer, 2,007,109 (1) :25 -32.
  • 7Linderholm BK,Lindahl T,Holmberg L,et al. The expres- sion of vascular endothelial growth factor correlates with mutunt p53 and poor prognosis in human breast cancer [J]. Cancer Res,2001,61(5) :2 256 -2 260.
  • 8Sharma G, Mirza S, Parshad R, et al. Clinical significance of Maspin promoter methylation and loss of its protein expres- sion in invasive ductal breast carcinoma: correlation with VEGF-A and MTA1 expression [ J ]. Turnout Biol, 2011,32 (1) :23 -32.
  • 9Tischkowitz M,Brunet JS,Begin LR,et al. Use of immuno- histochemical markers can refine prognosis in triple negative breast cancer[J]. BMC Cancer,2007, (7) :134.
  • 10刘畅,曹仁贤,陶松桔.VEGF在乳腺癌组织与血清中的表达及临床意义[J].实用预防医学,2012,19(8):1245-1247. 被引量:4

引证文献1

二级引证文献8

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部