聚(衣康酸-癸二酸)的合成及其生物降解性能

Synthesis and in vitro degradation of poly (sebacic-co-itaconic anhydrides)

用癸二酸和衣康酸通过真空熔融缩聚的方法合成了一系列聚（癸二酸-衣康酸）共聚酸酐（P（IA-co-SA））。用热失重（TG）、核磁共振（^1H-NMR）、傅立叶红外光谱（FT-IR）、凝胶渗透色谱（GPC）等手段对共聚酸酐进行了表征,并研究了共聚酸酐在磷酸盐缓冲溶液中的体外降解性能。结果表明,P（IA-co-SA）是一类可降解高分子材料,其体外降解速度随癸二酸（SA）在共聚酸酐中比例的提高而变慢。

Poly（sebacic-co-itaconic） anhydrides （P（IA-co-SA）） are successfully prepared by melting condensation under high vacuum condition from sebacic anhydride and itaconic anhydride.The copolyanhydrides are characterized by Thermogravimetry （TG）,Nuclear magnetic resonance （^1H-NMR）,Fourier transform infrared （FT-IR） and Gel permeation chromatography （GPC）.In vitro degradation of the copolyanhydrides in phosphate buffer solutions are also determined.The result shows that P （IA-co-SA） is a kind of biopolymer which degradation velocity becomes slow with the increasing of SA ratio in the coploymer.