摘要
O-GlcNAc糖基化修饰作为一种特殊的蛋白质翻译后修饰形式,动态调节细胞信号传导途径中很多酶的功能,与磷酸修饰有"阴阳调节"关系,正在成为研究的热点。本文综述了近年来O-GlcNAc糖基化修饰酶及其供体底物的研究进展。
A hallmark of signal transduction is the dynamic and inducible post-translational modification of proteins. In addition to the well characterized phosphorylation of proteins,many nuclear and cytoplasmic proteins are covalently modified by the linkage of monosaccharide N-acetylglucosamine（GlcNAc） to serine or threonine,a reaction catalyzed by O-GlcNAc transferase（OGT） . More and more evidences have indicated that the O-GlcNAc modification has the yin–yang relationship with phosphorylation. Herein,newly results about enzymes and substrate were reviewed.
基金
高等学校博士学科点专项科研基金(20030003049)
