摘要
5-三氟甲基-1,3,4-噻二唑脲类化合物(2)可以通过中间体(1)和取代胺在微波反应条件下非常容易地得到。目标化合物(2)通过核磁共振氢谱,液质联用质谱,元素分析和单晶衍射的数据来确认。5-三氟甲基-1,3,4-噻二唑脲类化合物(2)具有较低的除草活性和杀虫活性,但是具有一定的杀菌活性。其中有些化合物具有较好的植物生长调节作用。
A simple and efficient method is developed for the synthesis of 5-（trifluoromethyl）-1,3,4-thiadiazol ureas（2） from heterocyclic amino compounds and 1-phenyl-5-（trifluoromethyl）-1,3, 4-thiadiazol-2-yl carbamate （1） under solvent conditions using microwave irradiation.The structures of the titled compounds 2 are characterized by 1HNMR, LC-MS, elemental analysis and X-ray data. The results of the biological activities of the title compounds indicate that the titled compounds have low herbicidal and insecticidal activities, but good fungicidal activities. Some of them have good plant growth regulation activities.
关键词
有机化学
5-三氟甲基-1
3
4-噻二唑脲
微波
有机合成
生物活性
organic chemistry
5-（trifluoromethyl）-1
3
4-thiadiazol ureas
microwave
organic synthesis
biological activities
