孕晚期注射乙肝免疫球蛋白对乙型肝炎病毒母婴传播阻断率影响的探讨

The effect of antepartum injection of hepatitis B immunoglobulin on blocking the mother-to-infant transmission of HBV

目的探讨孕晚期注射乙肝免疫球蛋白(HBIG)对乙型肝炎病毒(HBV)母婴传播阻断率的影响。方法对103例慢性HBV携带孕妇于孕晚期按1∶1比例随机分为注射HBIG组和对照组,两组新生儿出生2h内均尽快注射HBIG200IU,基因重组酵母乙肝疫苗每次10μg,按0、1、6月方案注射。新生儿于7月龄及12月龄时检测外周血HBV标记物。结果孕晚期注射HBIG组51例和对照组52例孕妇所生新生儿共103例,在7月龄、12月龄时均无HBV携带,阻断率均达100%。结论新生儿出生2h内尽快注射HBIG200IU,同时按0、1、6月方案规范注射乙肝疫苗,即可获得满意的HBV母婴传播阻断效果;孕晚期注射HBIG对提高HBV母婴传播阻断率无显著意义。

Objective To investigate the effect of antepartum injection of hepatitis B immunoglobulin on blocking the mother-to-infant transmission of HBV. Methods One hundred and three pregnant women of chronic hepatitis B virus carrier were randomly divided into two groups： HBIG injection group and control group. All newborns were injected HBIG 200 IU within two hours after birth and hepatitis B vaccine 10μg each time immediately, one month and six months after birth. HBV markers were detected when they were 7 and 12 months old. Results All 103 newborns were not HBV carrier when they were 7 and 12 months old, the blocking rate is 100%. Conclusions The effect of blocking mother-to-infant HBV transmission is satisfied by injecting newbotns with HBIG 200 IU within two hours after birth and hepatitis B vaccine 10μg each time immediately, one month and six months after birth. Antepartum injection of HBIG couldn＇ t improve the blocking rate of mother-to-infant HBV transmission.