骨形成蛋白2及骨形成蛋白4在牙胚发育中的时空表达及意义

The Express and Significance of Bone Morphogenetic Protein-2 and Protein-4 during Different Stages and Periend of Tooth Development

牙齿发育初期和后期起调节作用的一些信号分子中,骨形成蛋白是与骨和牙齿形成相关的生长因子,作为形态生成信号在牙齿发育不同时期调控上皮与间充质间相互作用。牙胚发育过程中,BMP-2、BMP-4在牙胚发育各个时期的表达提示其在牙胚发育中的作用。研究表明,BMP-2、BMP-4作为上皮-间充质相互作用的继发调节信号参与牙齿发育,BMP-2参与调控牙乳头细胞分化形成成牙本质细胞;BMP-4与多种细胞因子相互作用参与调控牙型的形成。

Bone morphogenetic protein（BMP） families which act as morphogenefic signals mediating tissue interactions at various stages of tooth development. Bone morphogenetic protein, is a well-known growth factor and signal molecular. It has been proved to be involved in the development of many organs such as bone. BMP-2 or BMP-4 expressed in the dental epithelium and mesenchyme at different stages of develop- ment,to signal different cellular activities in a time-and tissue-specific way. BMP-2 was suggested to be in- volved in the formation of an epithelial signaling center, the primary enamel knot, while BMP-4 would mediate the condensation of the mesenehyme.