摘要
内脂素(visfatin)是近来发现的脂肪细胞分泌的一种细胞因子,可分布于多种器官,多种因素影响其表达。内脂素的基因结构、蛋白结构目前已研究较清楚。内脂素具有促炎作用、免疫反应和烟酰胺磷酸核糖转移酶活性。新近研究认为,内脂素缺乏直接的类胰岛素作用;内脂素可能参与2型糖尿病及相关肾病的发生发展,但也可能抑制其过程,因此,内脂素在2型糖尿病进展过程中的作用有待进一步研究。
As an adipocytokines recently discovered,visfatin can be found in many organs and its expression can be affected by many factors.Its gene and protein structures have been known.Visfatin can be involved in inflammatory response and reaction,with a nicotinamide phosphatase activity.Recent studies suggest that visfatin lacks a direct insulin-like effect; visfatin may accelerate the development of type 2 diabetes mellitus and related renal diseases but inhibit the process.Therefore,the role of visfatin in type 2 diabetes mellitus and related renal diseases remain to be further studied.
出处
《医学综述》
2010年第15期2329-2332,共4页
Medical Recapitulate
关键词
内脂素
糖尿病
肾病
Visfatin
Diabetes mellitus
Renal disease
