^131I治疗甲亢604例近期疗效分析

目的分析^131I治疗甲亢近期临床疗效。方法根据甲状腺质量和最高吸碘率等给予604例甲亢患者个性化^131I治疗，^131I于治疗后1、3、6、12个月随访，对甲亢、Graves眼病、甲亢性心脏病、低钾周期性麻痹、谷丙转氨酶升高、粒细胞减少及甲状腺大小等的转归进行回顾性分析。结果痊愈374例（61．9％），部分缓解101例（16．8％），甲减112例（18．5％），无效17（2．8％），总有效率为97．2％，治愈率为80．4％。^131I治疗Graves眼病总有效率83．7％，治疗甲亢性心脏病总有效率95．6％，同时可以缓解低钾周期性麻痹症状，改善肝功能，升高粒细胞，缩小甲状腺。结论^131I治疗甲亢及其伴发症安全有效，但要注意甲减等并发症的发生。

Objective To analyze the short - term clinical efficacy of ^131I therapy in hyperthyroidism. Methods 604 patients with hyperthyroidism were treated with individual ^131I therapy based on the quality and the highest thyroid iodine absorption rate, All patients were followed up for 1, 3,6 and 12 months after ^131I treatment, the outcome of Graves ophthalmopathy, hyperthyroidism heart disease, hypokalemic periodic paralysis, alanine aminotransferase increased, neutropenia and thyroid mass were analyzed retrospectively. Results Of the 604 patients, 61.9% （374/604） recovered, 16. 8% （101/604） were partial remission, 18.5% （112/604）were hypothyroidism, 2. 8% （17/604）were ineffective, total effective rate was 9% 2% , the cure rate was 80. 4%. ^131I treatment of graves eye disease had a total effective rate of 83.7% , total effective rate in treating hyperthyroidism heart was 95.6%, while periodic paralysis could relieve symptoms, improve liver function, elevated neutrophil and the decreased thyroid mass （ P 〈 0. 01 ）. Conclusion ~31I therapy for hyperthyroidism is safe and effective, can be used as the preferred treatment, but the complications of hypothyroidism else must be considered.