尼美舒利短期治疗小儿高热的获益风险分析

The benefits and risks of short-term therapy with nimesulide for children with high fever

目的 探讨尼美舒利短期用于小儿退热治疗的疗效及安全性.方法 通过与两种小儿常用退热药的对比治疗进行评价.将99例上呼吸道感染伴高热的患儿,随机分为Ⅰ、Ⅱ、Ⅲ三组,分别予口服尼美舒利、对乙酰氨基酚、布洛芬治疗,疗程≤3天.观察不良反应（ADRs）及首次用药后体温变化情况.结果 尼美舒利组（Ⅰ组）在治疗后1h、4 h、6h的体温下降及退热持续总有效率与其他两组比较,P均＜0.01;不良反应发生率Ⅰ组与Ⅱ、Ⅲ组比较P均＜0.05,Ⅰ组大量出汗较突出,与其它两组比较P＜0.05.结论 尼美舒利比其它两药退热起效快、持续时间较长、不良反应少,但大量出汗较明显.认为短期应用尚安全.

Objective To investigate the safety and efficacy of short-term therapy with nimesulide for children with high fever. Methods The efficacy of two types of antifebrile drug was assessed. 99 children with upper respiratory tract infection were randomly assigned to receive oral nimesulide （group Ⅰ）, acetami-nophen （group Ⅱ）, or Ibuprofen （group Ⅲ） for 3 days or shorter. The adverse reactions and the changes in body temperature after the first treatment were observed. Results The total effective rates of body temperature decrease and defervesce time in group Ⅰ were compared with those in the other two groups （P〈0.01）. The incidence of adverse reactions was compared between group Ⅰ and groups Ⅱ and Ⅲ（P〈0.05）. More children has profuse sweating in group Ⅰ than in groups Ⅱ and Ⅲ（P〈0.05）. Conclusions Nimesulide has a quicker onset of antifebrile, longer lasting time, less adverse reactions but causes profuse sweating more obviously. The short-term therapy with nimesulide is safe.