2Castren E, Voikar V, Rantamaki T. Role of neurotrophie factors in depression[J]. Curr Opin Pharmacol, 2007, 7( 1 ) : 18 -21.
3Karege F, Perret G, Bondolfi G, et al. Decreased serum brain-derived neurotrophic factor levels in major depressed patients [ J ]. Psychiatry Res, 2002, 109(2): 143-148.
4Karege F, Vaudan G, Schwald M, et al. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs[ J]. Brain Res Mol Brain Res, 2005, 136( 1 - 2) : 29 -37.
5Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety[J].Nat Neurosci, 2007, 10(9) : 1089 -1093.
6Angelucci F, Brene S, Mathe A A. BDNF in schizophrenia,depression and corresponding animal models [ J]. Mol Psychiatry, 2005, 10(4) : 345 -352.
7Otsuki K, Uchida S, Watanuki T, et al. Altered expression of neurotrophic factors in patients with major depression [ J ]. J Psychiatr Res, 2008, 42(14) : 1145 -1153.
8Perera T D, Coplan J D, Lisanby S H, et al. Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates [ J ]. J Neurosci, 2007, 27 ( 18 ) : 4894 - 4901.
1Biondi B,Cooper DS.The clinical significance of subclinical thy-roid dysfunction[J].Endocr Rev,2008,29(1):76-131.
2Shanna K,Blaha MJ,Blumenthal RS,et.al.Clinical and research applications of carotid intima-media thickness[J].Am J Cardiol,2009,103(9):1316-1320.
3Shenkin SD,Bastin ME,MacG illivray TJ,et al.Carotid intimamedia thickness and cerebrovascular disease in conmaunity dwehing older people without stroke[J].Stroke,2010,41(9):2083-2086.
4Aguado F,Carmona MA,Pozas E,et al.BDNF regulates spontaneous corre-lated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Clcotransporter KCC2[J].Development,2003,130(12):67-80.
5Gorski JA,Zeiler SR,Tamowski S,et al.Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites[J].J Neurosci,2003,23(68):56-65.
6Nagahara AH,Tuszynski MH.Potential therapeutic uses of BDNF in neurological and psychiatric disorders[J].Nat Rev Drug Dis-cov,2011,10(3):209-219.
