米非司酮配合聚维酮碘液介入治疗卵巢子宫内膜异位囊肿42例

Clinical study for mifepristone combination with povidone lodine to treat heterotopic endmetrial cyst

目的:观察米非司酮配合超声介入聚维酮碘液(povidone iondine,PI)治疗子宫内膜异位囊肿的疗效。方法:对72例盆腔子宫内膜异位囊肿的患者在阴道超声引导下行囊肿穿刺、抽吸并注射PI进行治疗。治疗组42例于当日起口服米非司酮(250mg,qd)3～6个月;对照组30例单行囊肿注入PI治疗。随访2年,比较两组治疗后的复发率及米非司酮的辅助治疗和副反应。结果:治疗组和对照组的复发率1年各为4.8%和26.7%,2年各为7.1%和30.0%。两组对比有显著差异(P<0.01),治疗组1年和2年复发率比较无显著差异(P>0.05)。结论:加用米非司酮治疗3～6个月可有效地降低子宫内膜异位囊肿穿刺注入治疗的复发率,副反应小,是一种安全高效尤对手术后复发盆腔粘连不宜手术的患者适用。

Objective：The obsevation of effective treatment to heterotopic endmetrial cyst by mifepristone and ultrasound guided puncturing matching with povidone lodine soluton.Methods：To the 72 patients of pelvic heterotopic endmetrial cyst,the treatment was using the vagina ultrasound guided puncturing to paracentesis,suction and inject povidone lodine soluton on the cyst.42 cases of treatment group oral mifepristone（250mg）3 to 6 months from the first day,the other 30 cases of control group were injected povidone lodine soluton on the cyst.Through 2-year＇s follow-up,compared the relapse rate of the two groups after using different treatments,and the adjuvant therapy and the side effects of mifepristone.Results：The 1-year＇s relapse rates of treatment group and control group were 4.8% and 26.7% respectively,2-year＇s relapse rates were 7.1% and 30.0% respectively.The two groups were different significantly（P〈0.01）;Treatment group for the relapse rates of the one year＇s and the two year＇s showed no significant difference（P〉0.05）.Conclusions：When the doctor using the treatment of suction and injection on heterotopic endmetrial cyst,if plusing with mifepristone for 3 to 6 months,the relapse rates would be effective reduced,and the side effects were less.So it could be seen as a safe and effficent treatment,especially suitable for the patients who had a recurrence of pelvic adhesions merged post-operative after surgery.