12周游泳运动对老龄小鼠免疫细胞功能的影响

The Influence of 12-week-swimming Training on the Function of Immunocyte in Aged Mice

对游泳１２周后的老龄Ｃ５７ＢＬ／６小鼠脾脏Ｔ细胞对ＣｏｎＡ的增殖反应能力、ＮＫ细胞活性及ＩＬ－１活性进行了研究。结果：（１）与年轻小鼠相比，老龄小鼠Ｔ淋巴细胞对ＣｏｎＡ的增殖能力、ＮＫ细胞活性、ＩＬ－１活性略有下降，但无显著差异（Ｐ＜０．０５）。（２）１２周训练后，隔天训练的老龄鼠Ｔ淋巴细胞对ＣｏｎＡ的增殖反应能力显著升高。（３）每天训练的老龄小鼠Ｔ淋巴细胞的增殖反应能力下降（Ｐ＜０．０５）。（４）１２周的训练没有使ＮＫ亚细胞和ＩＬ－１的活性发生显著性变化。

This study was designed to examined the effect of 12-week-swimming training on cell proliferation responses(stimulated by ConA),cyto- toxic activity of NK cells and splenic cell IL-1 production in aged mice.The findings: (1)Compared with the young mice, there were no signifi- cant decreases of T cell proliferation resonse, cytotoxic of NK cells and IL-1 production in the aged mice. (2)T cell proliferation response in the aged mice (trained every two days)increased significantly. (3)T cell proliferation declined in the aged mice (trained everyday) (P < 0.05) . (4)There were no significant changes of cytotoxic activity of NK cells and IL-1 production after 12 weeks.