益肤霜软膏中红霉素的稳定性测定

STABILITY OF ERYTHROMYCIN IN YI-FU-SHUANG OINTMENT

采用温度加速实验恒温法预测益肤霜软膏中红霉素的稳定性。用ＨＰＬＣ法测定含量，以Ａｒｒｈｅｎｉｕｓ指数定律进行计算，红霉素的降解规律符合一级动力学，预测红霉素在２５℃时的ｔ０．９为１．３年。红霉素的平均回收率为９７．３％ （ＲＳＤ＝ ４．１％ ）

Stability of erythrom ycin (1) in Yi-Fu-Shuang ointment was observed with classicalconstant tem perature method.1 was determined by a RP-HPLCmethod.Its decomposition wascom putedwith Arrheniuslaw.Thet0.9 of1 at25℃wascalculated to be1. 3 years.The average recovery of1 in Yi-Fu-Shuang ointmentwas 97.3% (RSD= 4.1% ).