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大肠癌环氧化酶-2调控的研究进展 被引量：2

Regulatory role of cyclooxygenase-2 in pathogenesis of colorectal cancer
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摘要 Cyclooxygenase-2(COX-2) has a close relationship with carcinogenesis and development of colorectal cancer.More than 80%-90% colorectal cancer shows over-expression of COX-2.The carcinogenic functions of COX-2 include inhibiting apoptosis of tumor cells,enhancing cell adhesion and neoplasm invasiveness,and promoting angiogenesis.The increasing evidence from experiments in vitro and in vivo indicates that regulation of COX-2 is a comprehensive process in the pathogenesis of colorectal cancer.This review discusses the updated investigations on COX-2 regulation at transcriptional and post-transcriptional levels,and related signal axis. Cyclooxygenase-2（COX-2） has a close relationship with carcinogenesis and development of colorectal cancer.More than 80%-90% colorectal cancer shows over-expression of COX-2.The carcinogenic functions of COX-2 include inhibiting apoptosis of tumor cells,enhancing cell adhesion and neoplasm invasiveness,and promoting angiogenesis.The increasing evidence from experiments in vitro and in vivo indicates that regulation of COX-2 is a comprehensive process in the pathogenesis of colorectal cancer.This review discusses the updated investigations on COX-2 regulation at transcriptional and post-transcriptional levels,and related signal axis.
作者 刘静 范忠泽
机构地区 上海市中医医院肿瘤科 上海市普陀区中心医院肿瘤科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2010年第8期1646-1649,共4页 Chinese Journal of Pathophysiology
基金 上海市自然科学基金资助项目(No.08ZR1419300)
关键词 环氧化酶2 结直肠肿瘤 信号转导通路 Cyclooxygenase-2 Colorectal neoplasms Signal transduction pathway
分类号 R363 [医药卫生—病理学]
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参考文献33

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二级参考文献11

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中国病理生理杂志
2010年 第8期

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