摘要
Serum creatinine and urine output is not sensitive for early detection and degree evaluation of acute kidney injury(AKI).Recently,triggered by high-throughput genomics and proteomics,identification of disease-related proteins has been revolutionized.The proposed biomarkers of AKI,such as kidney injury molecule(KIM-1),neutrophil gelatinase associated lipocalin(NGAL),interleukin-18(IL-18),sodium/hydrogen exchanger isoform 3(NHE3),spermidine/spermine acetyltransferase(SAT),and so on,are involved in various pathological processes,including immunity,cell structure,cell-cycle and signal transduction.More clinical and experimental investigations are needed to identify more biomarkers which are useful for early diagnosis of AKI.
Serum creatinine and urine output is not sensitive for early detection and degree evaluation of acute kidney injury(AKI).Recently,triggered by high-throughput genomics and proteomics,identification of disease-related proteins has been revolutionized.The proposed biomarkers of AKI,such as kidney injury molecule(KIM-1),neutrophil gelatinase associated lipocalin(NGAL),interleukin-18(IL-18),sodium/hydrogen exchanger isoform 3(NHE3),spermidine/spermine acetyltransferase(SAT),and so on,are involved in various pathological processes,including immunity,cell structure,cell-cycle and signal transduction.More clinical and experimental investigations are needed to identify more biomarkers which are useful for early diagnosis of AKI.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2010年第8期1650-1653,1661,共5页
Chinese Journal of Pathophysiology
基金
国家科技支撑计划资助项目(No.2007BAI04B10)