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急性肾损伤相关生物标志物的研究进展 被引量：21

Research advance in biomarkers of acute kidney injury
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摘要 Serum creatinine and urine output is not sensitive for early detection and degree evaluation of acute kidney injury(AKI).Recently,triggered by high-throughput genomics and proteomics,identification of disease-related proteins has been revolutionized.The proposed biomarkers of AKI,such as kidney injury molecule(KIM-1),neutrophil gelatinase associated lipocalin(NGAL),interleukin-18(IL-18),sodium/hydrogen exchanger isoform 3(NHE3),spermidine/spermine acetyltransferase(SAT),and so on,are involved in various pathological processes,including immunity,cell structure,cell-cycle and signal transduction.More clinical and experimental investigations are needed to identify more biomarkers which are useful for early diagnosis of AKI. Serum creatinine and urine output is not sensitive for early detection and degree evaluation of acute kidney injury（AKI）.Recently,triggered by high-throughput genomics and proteomics,identification of disease-related proteins has been revolutionized.The proposed biomarkers of AKI,such as kidney injury molecule（KIM-1）,neutrophil gelatinase associated lipocalin（NGAL）,interleukin-18（IL-18）,sodium/hydrogen exchanger isoform 3（NHE3）,spermidine/spermine acetyltransferase（SAT）,and so on,are involved in various pathological processes,including immunity,cell structure,cell-cycle and signal transduction.More clinical and experimental investigations are needed to identify more biomarkers which are useful for early diagnosis of AKI.
作者 吴昱 李晓玫
机构地区 北京大学第一医院肾内科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2010年第8期1650-1653,1661,共5页 Chinese Journal of Pathophysiology
基金 国家科技支撑计划资助项目(No.2007BAI04B10)
关键词 急性肾损伤 生物标志物 Acute kidney injury Biomarker
分类号 R593 [医药卫生—内科学]
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参考文献26

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二级参考文献18

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中国病理生理杂志
2010年 第8期

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