对生物环境因素敏感的荧光探针

Biologically Environment-Sensitive Fluorescent Probes

生物体中微环境的改变与许多生理、病理过程密切相关。因此,获取生物体系中局部环境信息、监控微环境的改变,对相关疾病的早期诊断与病理研究具有重要的意义。荧光探针由于具有分析灵敏度高、样品时空分辨能力强等特点,已在该方面获得了广泛的应用。根据不同的环境敏感性,本文简要评述对极性、pH、黏度及温度因素敏感的荧光探针及其在生命科学领域应用的研究进展,包括我们实验室近年来在该方面所取得的一些研究结果。

The alterations of locally environmental parameters（e.g.polarity,pH,viscosity and temperature） in biosystems correlate closely with some physiological function disorders.Therefore,the precise measurements of these parameters are of great importance for the explanation of complicated biological processes and diagnoses of some related diseases.Because of their high spatial and temporal resolution capability,many environment-sensitive fluorescent probes have been developed and used in life sciences.In this paper,a brief review is given on the progress and applications of various biologically environment-sensitive fluorescent probes,including some of the related results from our laboratory.