Maspin与宫颈癌新辅助化疗疗效的相关性研究

Correlation between expression of maspin and efficacy of neoadjuvant chemotherapy for cervical carcinoma

目的:探讨maspin在宫颈鳞癌新辅助化疗(NACT)前后表达的意义。方法:采用免疫组化方法检测30例行NACT患者的宫颈鳞癌组织及同期30例正常宫颈组织maspin的表达。结果:NACT前后maspin阳性表达率分别为36.7%和66.7%,NACT总有效率83.3%,其中完全缓解率30%,部分缓解率53.3%,稳定或无进展率16.7%。临床部分缓解组NACT后maspin的阳性率与NACT前相比明显增加,差异有统计学意义(P<0.05);完全缓解组及无进展组NACT后maspin的阳性率与NACT前相比也有增高,但差异无统计学意义。NACT后maspin阳性表达率在Ⅰb-Ⅱa期、Ⅱb-Ⅲb期均明显增高,Ⅱb-Ⅲb期NACT前后maspin阳性表达率的差异比较有统计学意义(P<0.05),而Ⅰb-Ⅱa期NACT前后maspin阳性表达率的差异比较无统计学意义。结论:宫颈鳞癌新辅助化疗后maspin阳性表达率明显高于化疗前,可能与化疗敏感性密切相关,Maspin可能作为判断宫颈鳞癌新辅助化疗敏感性的指标。

Objective： To explore the relationship between the expression of maspin and efficacy of neoadjuvant chemotherapy for squamous carcinoma of the cervix. Methods： Maspin was examined by immunohistochemical staining in 30 cervical cancer samples. Results： The expression of maspin after neoadjuvant chemotherapy was 66.7%,significantly higher than before neoadjuvant chemotherapy 36.7%（P0.05）.After NACT,total clinical response ratio of NACT was 83.3%,30% of patients with complete remission and 53.3% with partial remission 16.7% of patients with stable disease.In partial remission cases,the expression of maspin after NACT increased significantly（P0.05）;In complete remission and stable disease cases,the expression of maspin after NACT had no obvious change（P0.05）;Maspin before and after NACT in complete remission cases and in partial remission cases was obvious different.The increase of maspin after NACT in complete remission cases was more obvious than that in partial remission cases.In different FIGO stages（Ib-IIIb）,there was the significant difference of Ⅱb-Ⅲb stage after NACT,significance was found in maspin before and after NACT（P0.05）. Conclusion： The expression of maspin as a molecular marker could guide chemotherapy and predict the response to NACT in cervical cancer.