检测血清纤维连接蛋白(FN)在盆腔放射性损伤中的临床价值

Changes and significance of serum oibronectin in radiation damage of cavitas pelvis

目的:初步探讨血清纤维连接蛋白(FN)与盆腔放射性损伤的关系及其意义。方法:采用酶联免疫吸附法(ELISA)动态检测Ⅱ-Ⅲ期妇科肿瘤患者在放疗前、放疗中、放疗结束及放疗后随诊期间血清FN的含量变化。结果:血清FN水平在放疗开始后即出现明显的升高趋势,至1周时达第一高峰,此后在整个放疗期间呈间断性上升,至放疗结束时达第二高峰。发生放射性反应的患者在放疗结束后仍旧呈现持续性升高,而无放射性反应者表现为逐渐下降。结论:血清FN与放射治疗密切相关,可随放射治疗剂量的增加而升高,而与是否发生急性放射性损伤无关。在放射性损伤的发展过程中是一个迟发反应标记物。

Objective： To study the relation betweens erum fibronectin （FN）and radiation damage in cavitas pelvis. Methods： Detecting dynamically serum FN in patients with Ⅱ-Ⅲ stage gynecology tumor during radiotherapy and follow-up by enzyme linked immunosorbent assay（ELISA）. Results： The contents of serum FN had enhanced in radiotherapy initial phase and reached the first peak in first weekthen,it rose intermittently and to the second peak in radiotherapy end.The contents of serum FN still gradually rose in patients with radiation damage while dareased in patients of no radiation damage. Conclusion： The contents of serum FN rised gradually along with radiotherapeutic dose increase and correlated closely with radiation damage.It was a late response marker for development of radiation damage.