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CD47与白血病干细胞 被引量：3

CD47 and Leukemia Stem Cells——Review
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摘要 CD47,又称整联蛋白相关蛋白(integrin-associated protein,IAP),是一种免疫球蛋白样蛋白质,可通过与巨噬细胞上的抑制性受体信号调节蛋白alpha链(signal regulatory protein α chain,SIRPa)结合,降低吞噬细胞的吞噬活性。正常造血干细胞(HSC)上CD47的表达有助于保持其在机体内的相对稳定,但是另一方面CD47在AML患者的白血病干细胞(LSC)中高表达,LSC通过CD47的高表达来降低自身被巨噬细胞的吞噬,从而降低机体固有免疫系统对LSC的清除作用。本文将就CD47在HSC和LSC上的表达、功能以及白血病预后和靶向治疗中的作用加以综述。 CD47, also known as integrin-associated protein （ IAP）, is an immunoglubulin-like protein. It can inhibit the phagocytosis of macrophages through binding with signal-regulatory protein α chain of inhibitory receptor on macrophage （SIRPtx）. The expression of CD47 on normal hematopoietic stem cells （HSCs） is useful for maintaining the stability of HSCs in body, but the high expression of CD47 existed on leukemia stem cell （LSCs） of AML patients which can reduce the macrophage-induced phagocytosis to LSCs and decrease the clearance of innate immune system of organism to LSCs. In this article, the expression and function of CD47 on HSCs and LSCs as well as the role of CD47 in the prognosis and target therapy of AML are reviewed.
作者 程千松 王兴兵
机构地区 安徽医科大学附属省立医院血液科
出处 《中国实验血液学杂志》 CAS CSCD 2010年第4期1088-1091,共4页 Journal of Experimental Hematology
基金 国家自然科学基金 编号30700329 安徽省优秀青年科技基金 编号08040106810
关键词 CD47 SIRPa 白血病干细胞 CD47 SIRPa leukemia stem cell
分类号 R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献20

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二级参考文献24

  • 1Brown EJ, Frazier WA. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol, 2001; 11: 130-135.
  • 2Mawby WJ, Holmes CH, Anstee DJ, et al. Isolation and characterization of CD47 glycoprotein: a muhispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3. Biochem J, 1994; 304:525 - 530.
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共引文献8

同被引文献47

  • 1李英华,罗建民.白血病形成中JAK/STAT信号通路的持续激活[J].国际病理科学与临床杂志,2006,26(5):398-402. 被引量：6
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  • 3Hussein MR, Hassan HI. Analysis of the mononuclear in- flammatory cell infiltrate in the normal breast, benign pro- liferative breast disease, in situ and infiltrating ductal breast carcinomas; preliminary observations [J]. J Clin Pathol,2006,59(8) :972-977.
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中国实验血液学杂志
2010年 第4期

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