甲亢性心力衰竭患者血浆内源性洋地黄样因子的动态观察──附45例报告

Dynamic observation on changes of plasma endogenous digitalis like factor in heart failure of hyperthyroid heart disease

目的：了解甲状腺功能亢进（甲亢）性心脏病心力衰竭（甲亢并心衰）患者血浆内源性洋地黄样因子（ＥＤＦ）浓度动态变化的意义。方法：用放射免疫法测定了４５例甲亢并心衰患者和３３名正常人血浆ＥＤＦ浓度。结果：甲亢并心衰组血浆ＥＤＦ浓度明显低于正常组［甲亢并心衰组（０．４５±０．１８）μｇ／Ｌ，正常组（０．６６±０．２２）μｇ／Ｌ，Ｐ＜０．０１］，心衰纠正后血浆ＥＤＦ浓度明显升高［治疗前（０．４２±０．１７）μｇ／Ｌ，治疗后（０．６１±０．２４）μｇ／Ｌ；Ｐ＜０．０１］。结论：甲亢患者的ＥＤＦ分泌不足可能与心衰的发生有关。

Objective: To observe the dynamic changes of plasma endogenous digitalis like factor (EDF) in heart failure induced by hyperthyroid heart disease Methods: 45 cases of heart failure patients induced by hyperthyroid heart disease and 33 healthy subjects were observed, and their plasma EDF were determined with radioimmunoassay Results: The levels of plasma EDF in hyperthyroid heart failure patients were significantly lower than those in healthy subjects [hyperthyroid heart failure:(0 45±0 18) μg/L, healthy subjects:(0 66±0 24)μg/L, P <0 01]and the levels of plasma EDF in hyperthyroid heart failure patients remarkably elevated [(0 61±0 24)μg/L, P <0 01]after recovery from heart failure [(0 42±0 17)μg/L] Conclusion: The deficiency of plasma EDF may be related to hyperthyroid heart failure