氟哌啶醇对褪黑素免疫调节作用的影响

Effects of haloperidol on immune regulations of melatonin in mice

目的 :本文研究了氟哌啶醇 (haloperidol,Hal)对褪黑素 (melotonin ,MT)免疫调节作用的影响。方法 :小鼠自实验前 1周置于标准明暗周期交迭环境中饲养、自由摄食饮水。实验时分别测定小鼠外周血淋巴细胞百分率 (Lym% )、T -淋巴细胞百分率 (T -Lym % )与血清溶血素生成水平 (HC50 值 )。结果 :MT 2 0 μg/kg可以显著升高Lym %、T-Lym %与HC50 值 ,Hal 0 .4～ 1 .6mg/kg对小鼠Lym %、T -Lym %无直接影响 ,对HC50 值有一定影响 ,但均完全抑制MT升高Lym %、T -Lym %与HC50 值的作用。结论 :MT的免疫调节作用机制之一可能与多巴胺 (DA)受体介导有关。

OBJECTIVE:To study the effects of haloperidol(Hal) on immune regulation of melatonin(MT) in mice.METHODS:Mice were housed in a standardized light-dark cycle with food and water for a week before experiment.The lymphocyte percentage(Lym%),T-lymphocyte percentage(T-Lym%) and serum hemolysis formation(HC 50 value) in peripheral blood of mice were determined,respectively.RESULTS:MT(20μg/kg) significantly enhanced Lym%,T-Lym% and HC 50 value.Hal(0.4～1.6mg/kg) had no direct influence on Lym%,T-Lym% and HC 50 value,but completely depressed the effective immune enhancement of MT.CONCLUSION:One of mechanisms of MT immune enhancement may be the intermediation of dopamine receptor.