血管内皮生长因子在上皮性卵巢癌中的表达

Expression of vascular endothelial growth factor in epithelial ovarian cancer

目的：探讨上皮性卵巢癌中血管内皮生长因子（ＶＥＧＦ）的表达及意义．方法：以ＳＡＢＣ免疫组化方法检测了３７例上皮性卵巢癌中ＶＥＧＦ表达．结果：上皮性卵巢癌、交界性卵巢肿瘤及良性肿瘤中ＶＥＧＦ表达率分别为７２．９７％，７５．０％及３８．４６％，恶性肿瘤及交界性肿瘤中ＶＥＧＦ表达率较良性肿瘤明显增高（Ｐ＜０．０５），且前两者的ＶＥＧＦ强阳性表达率也较良性肿瘤明显增高（Ｐ＜０．０５）．上皮性卵巢癌中ＶＥＧＦ表达率与淋巴结转移密切相关（Ｐ＜０．０５）．恶性肿瘤不同病理分级及临床分期ＶＥＧＦ表达率无明显差异（Ｐ＞０．０５）．结论：ＶＥＧＦ在与上皮性卵巢癌有关的血管形成中可能起着重要作用．

AIM: To investigate VEGF expression in ovarian cancer for the implication of VEGF in tumorigenicity and metastasis of ovarian cancer. METHODS: Thirtyseven samples of ovarian cancer taken from Xijing Hospital were examined for VEGF expression by SABC immunohistochemical analysis. RESULTS: The positive rate of VEGF expression among malignant, borderline and benign tumors is 72.97%,75.00% and 38.46% respectively. The rates of VEGF expression in malignant and borderline tumors are higher than those of benign tumors (P<0.05) and the rates of VEGF strong expression in malignant and borderline tumors are also higher than those of benign tumors (P<0.05).Good correlations of VEGF expression were noted with lymph node metastasis (P<0.05). Statistical analysis did not show observable difference between VEGF expression and pathological grades as well as clinical cancer stages. CONCLUSION: VEGF plays an important role in the angiogenesis associated with epithelial ovarian cancer.