促凋亡基因bak在星形细胞瘤中的表达与意义

Immunocytochemical localization of mu opioid receptor in primary afferent neurons containing substance P or calcitonin gene related peptide. A light and electron microscope study in the rat

目的：研究促凋亡基因ｂａｋ在星形细胞瘤（Ａｓｔｒｏｃｙ－ｔｏｍａ）中的表达与意义．方法：采用兔抗人Ｂａｋ多克隆抗体及免疫组织化学ＳＡＢＣ法．结果：在６６例星形细胞瘤中，Ｂａｋ表达３９例（５９．１％）；１０例用于对照的正常脑组织中，Ｂａｋ阳性仅１例（１０％）．ｂａｋ在星形细胞瘤中的表达强于正常对照组（Ｐ＜０．０５），ｂａｋ在Ⅰ，Ⅱ，Ⅲ，Ⅳ级星形细胞瘤相互之间表达无显著差异（Ｐ＞０．０５），但在３１例低度恶性星形细胞瘤（ＷＨＯⅠ级～Ⅱ级）中表达强于在３５例高度恶性星形细胞瘤（ＷＨＯⅢ级～Ⅳ级）中的表达（Ｐ＜０．０５）．结论：促凋亡基因ｂａｋ在大部分星形细胞瘤中有不同程度表达，ｂａｋ可能参与星形细胞瘤的凋亡调变；其表达与星形细胞瘤分化有关．

Abstract Co expression of mu opioid receptor like immunoreactivity (MOR LI) with substance P (SP) or calcitonin gene related (CGRP) LI was observed in rat trigeminal and dorsal root ganglion neurons. In particular, MOR LI was found in axon terminals with SP or CGRP LI in laminae I and II of the medullary and spinal dorsal horns. MOR may be implicated in modulation of release of SP and CGRP from primary sensory afferents. Copyright 1998 Elsevier Science B.V. All rights reserved.