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血小板受体糖蛋白Ⅲa基因与心肌梗塞关系的研究 被引量:2

The relationship between platelet receptor glycoprotein IIIa gene and myocardial infarction in Chinese
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摘要 目的探讨血小板受体糖蛋白(GPIIa)基因变异与心肌梗塞(MI)发病的关系。方法运用变性梯度凝胶电泳(DGGE)技术对40例MI患者和相应数量健康人作对照行GPIIa基因全部外显子筛查。同时,以RFLP和ASO技术检测82例MI和68例健康人对照的GPIIa基因PlA多态性,并与50例美国健康白种人比较。结果发现GPIIa基因外显子5中存在核苷酸静止突变;150例中国人的GPIIaPIA多态基因型均为PlA1/PlA1,与美国白种人比较,差异有显著性。结论表明中国人群的血小板受体GPIIa基因与MI发病无相关性。 Objective To investigate the relationship between myocardial infarction and platelet glycoprotein receptor GPIIIa gene. Methods All exons of the GPIIIa gene were screened by denaturing gradient gel electrophoresis (DGGE) in 40 MI cases and number matched controls. Furthermore, P1A1/P1A2 polymorphism of GPIIIa gene was checked in 82 MI cases and 68 controls by RFLP and ASO, with the results being compared with 50 American Caucasian. Results A silent mutation existed in exon 5. The genotype of GPIIIa polymorphism was exclusively P1A1/P1A1 in Chinese, which differed significantly from that in American Caucasian. Conclusion Platelet receptor GPIIIa gene is not related to MI morbidity in Chinese.
出处 《中华心血管病杂志》 CAS CSCD 北大核心 1999年第2期111-112,共2页 Chinese Journal of Cardiology
基金 上海市科委重大项目基金 "863"高科技和美国史克药厂资助
关键词 心肌梗塞 血小板受体 糖蛋白 基因变异 myocardial infarction platelet receptor polymorphism silent mutation
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  • 1Kim H O,Transfusion,1995年,35卷,863页

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