HSB、GSTs和TNF血清学指标联合检测对肝癌诊断价值的临床评价

DETECTION OF SERUM HSB,GSTs AND TNF IN DIAGNOSIS OF PHC AND CLINICAL VALUE

为探讨肝癌特异性ＧＧＴ同工酶区带（ＨＳＢ）、谷胱苷肽－Ｓ－转换酶（ＧＳＴｓ）和肿瘤坏死因子（ＴＮＦ）３项血清学标志物浓度改变在肝癌诊断与鉴别中的临床价值，分别对肝癌、慢性肝病和肝外肿瘤进行定量检测分析。结果，肝癌组ＨＳＢ和ＧＳＴｓ浓度均明显高于慢性肝病和肝外肿瘤组（Ｐ＜０．０１）；ＴＮＦ浓度肝癌组明显高于慢性肝病组（Ｐ＜０．００１），但与肝外肿瘤组间无明显差异；肝癌组ＨＳＢ、ＧＳＴｓ和ＴＮＦ的阳性率分别为８８．６％、７８．１％和７４．３％，均显著高于另两组（Ｐ＜０．０１）。研究表明，ＨＳＢ定量检测优于ＧＳＴｓ和ＴＮＦ，多项指标联合分析有助于肝癌的诊断与鉴别。

To explore the alterations of three serum markers,concentrations in diagnosis of primary hepatocellular cancinoma(PHC) and clinical value of its differential diagnosis. The serum hepatoma specific band(HSB) activities of GGT, glautathione S-transferase(GSTs) and tumor necrosis factor(TNF) were quantitated in different patients with liver diseases. The concentrations of HSB and GSTs in patients with PHC increased significantly in comparison with chronic liver diseases and other tumors( P <0.001). The concentration of TNF in PHC was significantly higher than that in chronic liver diseases, but no differentiation was noted between PHC and other tumor groups. The positive rates of HSB, GSTs and TNF in PHC group were 88.6%, 78.1% and 74.3% ,respectively. These results indicate that the quantitative analysis of HSB activities of GGT is superior to GSTs and TNF. The combined detection of several markers was helpful to diagnosis and differential diagnosis of PHC.