摘要
应用免疫组化方法，对３２例人肝细胞肝癌的谷胱甘肽Ｓ－转移酶（ＧＳＴｓ）及同工酶进行原位检测，并以γ－谷氨酰转肽酶（γ－ＧＴ）作为对照，同时检测１１例肝硬化组织的ＧＳＴｓ酸性同工酶ＧＳＴ－π。结果显示，人肝细胞肝癌的ＧＳＴ－π阳性检出率高于肝硬化组织，尤其在高分化肝细胞肝癌中呈过量表达（８５％）；同时，肝细胞肝癌组织的ＧＳＴ－π阳性率显著高于γ－ＧＴ阳性率。提示ＧＳＴ－π有望成为人肝细胞肝癌的一种新的标志酶。
Glutathione S-transferase (GSTs) and its isoenzymes were studied in human hepatocellular carcinoma (HCC) of 32 patients by immunohistochemical stainning in comprison with -Glutamyl (-GT).Meanwhile 'anionic' transferase (GST-) was detected in the patients with liver cirrhosis (LC).The level of positive stainning of GST- was higher in HCC than in LC,especially,GST- is over expressed ( P <0.05) in well-differentiated tumors and the positive stainning of GST- in HCC is significantly stronger ( P <0.05) than that of -GT.The present data indicate that GST- is a useful marker in the diagnosis of human hepatocellular carcinoma.
出处
《南通医学院学报》
1999年第2期149-151,共3页
ACTA Academiae Medicinae Nantong
关键词
肝癌
原发性
GSTS
谷胱甘肽S
转移酶
同工酶
glutathion S-transferasehuman hepatocellular carcinomaimmunohistochemistryisoenzyme
