Ⅰ型变态反应与呼吸道合胞病毒毛细支气管炎喘鸣的关系

ROLE OF HYPERSENSITIVITY IN RECURRENT WHEEZING AFTER RESPIRATORY SYNCYTIAL VIRUS (RSV) INFECTION

本文从RSV特异的IgE抗体(RSV-IgE),嗜硷粒细胞和组织胺三方面,探讨了RSV毛细支气管炎喘鸣的发病机理。实验发现,RSV毛细支气管炎患儿的鼻咽分泌液(NPS)中RSV-IgE和组织胺显著升高,外周血嗜硷粒细胞绝对数升高,对 RSV抗原敏感性高,脱颗粒阳性率高。初步证实 IgE介导Ⅰ型变态反应参与了 RSV毛细支气管炎的发病。同时发现,RSV-IgE在患儿体内持续存在,这可能是 RSV毛细支气管炎喘鸣患儿在病后数年中反复出现喘鸣的原因之一。

We studied the RSV specific IgE antibody and histamine concentration in the NPS as well as the basophil count in peripheral blood from infants with RSV bronchiolitis. We found that during the acute phase, both the titers of RSV-IgE and the concentration of histamine arose significantly. The basophil count and basophil degranulation number in the presence of RSV antigen increased. All these suggest that hypersensiti-vity participate in the pathogenesis of RSV bronchiolitis. We also found RSV-IgE persisted a long time in the infants with RSV bronchiolitis, presumably playing an important role in recurrent wheezing after RSV infection for years.