HPV负荷量与子宫颈病变关系的研究

Association of human papillomavirus load with cervical diseases

目的探讨人乳头状瘤病毒(HPV)负荷量与子宫颈病变发生、发展的关系。方法选取229例子宫颈病变患者采用第二代杂交捕获法检测HPV负荷量,观察HPV负荷量和不同程度子宫颈病变的关系。结果 229例患者中慢性子宫颈炎57例,CIN111例(其中CINⅠ33例、CINⅡ18例、CINⅢ60例),子宫颈癌61例。不同程度子宫颈病变HPV-DNA负荷量的差别有统计学意义,且子宫颈病变的严重程度随HPV-DNA负荷量增大而增加。结论 HPV负荷量与子宫颈癌及其前期病变存在明显相关性。

Objective To investigate the association of human papillomavirus（HPV） load with occurrence and development of cervical diseases.Methods Two hundred and twenty-nine patients with cervical diseases were enrolled in the study.The HPV load was detected by hybrid capture Ⅱ（HC-Ⅱ） technique and the correlation of HPV load with cervical diseases was analyzed.Results Among 229 patients,there were 57 cases of chronic cervicitis,111 cases of cervical intraepithelial neoplasia（CIN） including 11 CINⅠ,18 CINⅡ and 60 CINⅢ,and 61 cases of cervical carcinoma.The HPV load increased with the increased severity of the cervical diseases.Conclusion There is an association between HPV viral load and cervical carcinoma and precancerous lesions.