奎硫平对老年精神分裂症患者生活质量的影响

Influence of quetiapine on quality of life in elderly patients with schizophrenia

目的:观察奎硫平、利培酮对老年精神分裂症患者生活质量及社会功能的影响。方法:将64例老年精神分裂症患者随机分为奎硫平治疗组和利培酮治疗组,疗程6个月。采用阳性与阴性症状量表(PANSS)评定疗效,生活质量综合评定问卷(GQOLI)评定生活质量,社会功能缺陷量表(SDSS)评定社会功能缺陷和治疗中出现的症状量表(TESS)评价不良反应。结果:治疗后两组PANSS评分有明显下降(P<0.01),两组间比较差异无统计学意义(P>0.05)。奎硫平组GQOLI评分和SDSS某些因子评分较利培酮组显著为好(P<0.01);不良反应明显少于利培酮组(P<0.01)。结论:奎硫平较利培酮治疗老年精神分裂症患者疗效相仿,但更能提高生活质量及社会功能。

Objective： To investigate influence of quetiapine and risperidone on quality of life and social function in elderly patients with schizophrenia. Method： A total of 64 elderly patients with schizophrenia were randomly treated with quetiapine or risperidone for 6 months. Positive and negative syndrome scale（PANSS） was used to assess efficacy,generic quality of life inventory （GQOLI） to assess quatity of life,social disability screening schedule（SDSS） to assess social function,and treatment emergent symptoms scale（TESS） to assess side effects. Results： After 6-month treatment,PANSS total scores in two groups significantly decreased （P 0. 01） ,there was no significant difference between two groups （P 0. 05） . Quetiapine group improved more significantly on GQOLI and SDSS total score as well as factor scores （P 0. 01） and showed fewer the side effects （P 0. 01） than risperidone group. Conclusion： Quetiapine has better effects for improving quality of life and social function in elderly patients with schizophrenia.