血清补体H因子在狼疮性肾炎患者中水平及临床意义

Level and clinical significance of factor H in serum samples from patients with lupus nephritis

目的:探讨血清补体H因子在狼疮性肾炎发病中的作用及临床意义。方法:收集40例狼疮性肾炎、30例系统性红斑狼疮无临床肾脏损害者和30名健康献血员(对照组)的血清,采用间接酶联免疫吸附试验法检测H因子,分析H因子水平与狼疮性肾炎病理类型的关系。结果:狼疮性肾炎组和系统性红斑狼疮无临床肾脏损害组H因子水平低于对照组(P<0.01,P<0.05)。血清中H因子水平,狼疮性肾炎Ⅳ型低于Ⅱ型,差异有统计学意义(P<0.01),但Ⅳ型与Ⅲ型、Ⅲ型与Ⅱ型差异无统计学意义(P>0.05)。结论:H因子水平降低可能参与狼疮性肾炎的发病过程,且与狼疮性肾炎病理类型有关,与狼疮性肾炎肾脏损伤程度可能有关。

Objective To explore the pathogenesis and clinical significance of complement factor H in patients with lupus nephritis.Methods A total of 40 cases of lupus nephritis,30 cases of systemic lupus erythematosus without clinical evidence of renal involvemetn and 30 normal controls were enrolled in our study.Indirect enzyme-linked immunosorbent assay was used to detect factor H.The correlation was analyzed between factor H and pathological phenotype.Results The level of factor H in patients with lupus nephritis and systemic lupus erythematosus were significantly lower than that in normal controls respectively（P0.01,P0.05）.In patients with lupus nephritis,the level of factor H in class Ⅳ was significantly lower than that in class Ⅱ（P0.01）,but there was no significant difference between class Ⅳ and class Ⅲ,and between class Ⅲ and class Ⅱ（P0.05）.Conclusion The decease of factor H may be involved in lupus nephritis.It is related to the pathological phenotype of lupus nephritis,and is probably related to the degree of renal injury in lupus nephritis.