不同药物雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效观察

Effect Observation of Atomization Inhalation with Different Drugs in Treating the Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的探讨不同药物雾化吸入治疗慢性阻塞性肺疾病(COPD)急性加重期的临床效果。方法将2009年1月～2010年1月间在我院住院治疗的COPD急性加重期患者60例随机分为观察组和对照组,观察组给予布地奈德联合硫酸特布他林雾化吸入,对照组给予布地奈德联合异丙托溴铵雾化吸入,评估治疗效果。结果治疗后两组PO2及PCO2均较治疗前明显改善,两者比较差异具有统计学意义(P<0.05);治疗后观察组PO2及PCO2改善情况与对照组比较差异无统计学意义(P>0.05)。治疗后两组FEV1均较治疗前明显改善,两者比较差异具有统计学意义(P<0.05);治疗后观察组FEV1改善情况与对照组比较差异无统计学意义(P>0.05)。观察组总有效率为93.33%,对照组为96.67%,两组比较差异无统计学意义(P>0.05)。两组患者均未见明显的药物不良反应。结论两种方案治疗COPD急性加重期疗效确切,效果等同,值得应用。

Objective To investigate the effect of atomization inhalation with different drugs in treating the patients with acute exacerbation of chronic obstructive pulmonary disease.Methods 60 cases with acute exacerbation of chronic obstructive pulmonary disease in our hospital from January 2009 to January 2010 were randomly divided into the observation group and the control group,the observation group was given the treatment of budesonide combined with terbutaline sulphate,and the control group was given the treatment of budesonide combined with ipratropium bromide,the effect was evaluated in the two groups.Results PO2 and PCO2 in the two groups after treatment were superior to those before treatment,and there was significant difference in them respectively（P0.05）.PO2 and PCO2 in the observation group after treatment was same to those in the control group,and there was no significant difference in them respectively（P0.05）.FEV1 in the two groups after treatment was superior to those before treatment,and there was significant difference in them respectively（P0.05）.FEV1 in the observation group after treatment was same to that in the control group,and there was no significant difference in them respectively（P0.05）.The total effective rate was 93.33% in observation group and 96.67% in control group,and there was no significant difference in them（P0.05）.The patients in both groups had no any significant adverse drug reactions.Conclusion The effect of atomization inhalation with different drugs in treating the patients with acute exacerbation of chronic obstructive pulmonary disease is obvious and equate,so they are worth being used.