抗精神病药引致上消化道出血17临床分析

Antipsychotics cause upper gastrointestinal bleeding and clinical analysis

目的：了解临床常用抗精神病药物引致上消化道出血的临床特征。方法：分析住院口服抗精神病药物引致上消化道出血17例精神分裂症患者的用药品种、剂量、临床表现、转归。结果：常用抗精神病药引致的上消化道出血64．71％（11／17）发生在第1次住院治疗时；口服单一常用抗精神病药引致上消化道出血发生率最低，为11．76％（2／17）；全部病例为急性发病，65％（11/17）有上腹不适、疼痛等先兆病状，35％（6／17）无症状；常用抗精神病药引致的上消化道出血76％（13／17）为轻度出血。结论：常用抗精神病药物有引致上消化道出血的副反应，应用H2受体拮抗剂或质子泵抑制剂治疗此类出血有效。临床上抗精神病药物尽可能单药口服。

PURPOSE：To sdudy used clinically antipsychotic caused the clinical features of upper gastrointestinal bleeding. METHODS AND MATERIALS：Analysis of oral antipsychotics of the drug varieties, dosage, clinical manifestation and the outcome in 17 cases of patients with schizophrenia, and summarize the concerning that caused upper gastrointestinal bleeding. RESULTS：Common antipsychotic cause of upper gastrointestinal bleeding 64.71%（11/17） in control group in first time during hospitalization, Single antipsychotic drugs commonly have less incidence of upper gastrointestinal bleeding for 11.76M （2/17）. All cases of acute onset, and65%（11/17） have epigastric discomfort, painetal. 35%（6/17） beasymptomatic. 76%（13/ 17） of upper gastrointestinal bleeding caused by Common antipsychotic is mild. CONCLUSIONS：Common antipsychotic drugs have caused side effects of upper gastrointestinal bleeding, and can be treated by application of H2 receptor antagonists or proton pump inhibitors, single antipsychotic drugs orally will be better.