摘要
目的：探讨应用低分子肝素（LMWH）与普通肝素（UFH）抗凝对长期维持血液透析患者血脂的影响。方法：选择用UFH抗凝血透6个月的维持血液透析患者60例，随机分成LMWH组（32例）和UFH组（28例），分别于入组开始和12个月结束时测胆固醇（CHOL）、甘油三腊（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、载腊蛋白A（APO～A1）、栽脂蛋白B（APOB）。结果：LMWH抗凝对脂质代谢无影响，UFH抗凝后TG、CHOL及APOB升高明显，P〈0．05。鲒论：低分子肝素抗凝对维持性血液透析患者血腊影响不大，肝素可导致其甘油三酯和胆固醇的升高。
Objective, To investigate the effect on blood fat with LMWH and UFH anticoagulation in maintenance hemodialysis patients. Method：60 patients with UFH anticoagulation （maintenance hemodialysis course 〉 6 month） were divided LMWH group（n= 32） and UFH group（n= 28）, CHOL.TG. HDL.LDL,APO--A1.APOB were measured before anticoagulation and post anticoagulation 12 month. Results： LMWH anticoagulation had no effect on lipid metabolism,but value of TG .CHOL .APOB become higher after anticoagulation with UFH,had distinct difference between two group. Conclusion.. LMWH had no effect on blood fat in hemodialysis patients,UFH could lead TG and CHOL to rise.
