糖尿病合并脑梗死认知功能障碍的治疗研究

The Treatment of Cognitive Dysfunction in Patients with Diabetes Complicated with Cerebral Infarction

目的探讨应用叶酸、维生素B12治疗糖尿病合并脑梗死(DCI)患者,对其血浆同型半胱氨酸(Hcy)水平的影响,及其对认知功能恢复的疗效。方法将60例DCI患者,按双盲方法分成两组,DCI-A组予补充叶酸、维生素,DCI-B组则否,两组患者同时接受缺血性卒中常规治疗。于入院24h内及治疗后第3个月的最后1d,分别测定各组血浆Hcy水平,并用MMSE量表了解患者治疗前后认知功能的改变。结果叶酸、维生素B12治疗3个月后患者的血浆Hcy水平降低。DCI-A组MMSE评分的提高明显高于DCI-B组(P<0.05)。结论应用叶酸、维生素B12治疗3个月,可显著降低患者的Hcy水平,而且较常规治疗对改善患者的认知功能有更好的疗效。

Objective To investigate the plasma homocysteine level and cognitive function in diabetic patients with cerebral infarction after treated by folic acid and Vitamin B12.Methods 60 diabetes patients with cerebral infarction were randomly divided into two groups,Group A were treated with folic acid and Vitamin B12,but group B were not treated.Patients were also receiving regular treatment of ischemic stroke.Plasma homocysteine was measured in the first 24 hours and the last day after the patients have been treated for 3 months.We also evaluate the cognition function by Mini-Mental State Examination Scale.Results The plasma homocysteine level was significantly decreased after the patients have been treated with folic acid and vitamin B12 for 3 months.The improvement of MMSE score in group A was significantly higher than in group B（P0.05）.Conclusion The plasma homocysteine level can be significantly decreased after the patients have been treated with folic acid and vitamin B12 for 3 months.Compared with conventional treatment,the cognition function improved better in patients who have been treated with folic acid and vitamin B12.