hs-CRP、脂蛋白a、尿酸与冠状动脉粥样硬化性心脏病的研究进展

The Progress on the Research of Hs-CRP,Lp(a),UA and Coronary Heart Disease

早期研究发现了200多个与冠状动脉粥样硬化性心脏病(CHD)有关的危险因素,起主要作用的有性别、吸烟、高血压、高血脂、糖尿病、体力活动减少、肥胖等,然而部分人群对上述危险因素给予积极有效控制后,急性冠状动脉事件发生率及病死率仍在上升。近年来大量的流行病学及实验研究发现,CHD的发生、发展还与其他一些危险因素,如炎症、促凝因素、脂蛋白、高尿酸血症、高同型半胱氨酸血症、低胆红素血症等密切相关。

More than 200 risk factors associated with coronary heart disease were found by numerous studies large number of studies.Gender,smoking,hypertension,hyperlipidemia,diabetes,reduced physical activity,obesity,etc.play a major role.While the incidence of acute coronary events and mortality is still rising even after active control of these risk factors.In recent years a large number of epidemiological and experimental study show that the occurrence and development of coronary heart disease are closely related with some risk factors such as inflammation,procoagulant factors,LDL,hyperuricemia,high homocysteine,low bilirubin hyperlipidemia and so on.