摘要
恶性心律失常是心肌梗死常见和严重的并发症,是一种复杂的病理过程,至今发病机制尚未完全阐明。近年来SCN5A、KCNQ1、KCNE1、KCNH2等离子通道相关基因的作用越来越受到重视,其参与心肌梗死后恶性心律失常的产生。目前基因治疗已开始应用于动物模型,早期实验及应用前景令人鼓舞。现就基因在心肌梗死后恶性心率失常的研究进展予以综述。
Malignant arrhythmia is a complex pathological process and a common complication following myocardial infarction（MI）.The pathogenesis of malignant arrhythmia remains unclear.In recent years,there is an increasingly emphasis on the role of genes.Researches have shown that gene participates in the ocur rence of malignant arrhythmia after MI and gene therapy has been used in animal models.This article reviews the effects of gene on the arrhythmia related to post-MI.
出处
《医学综述》
2010年第16期2420-2422,共3页
Medical Recapitulate
关键词
心肌梗死
恶性心律失常
基因
Myocardial infarction
Malignant arrhythmia
Gene
