儿童EB病毒性脑炎研究进展

Study Progress of Children with Epstein-Barr Viral Encephalitis

病毒性脑炎是儿童常见的中枢神经系统感染性疾病,EB病毒(EBV)也是儿童中枢神经系统病毒感染的常见病原之一。EBV侵犯中枢神经系统后,可导致脑水肿、出血、免疫复合物沉积、脑组织脱髓鞘样改变等,临床可表现为急性起病或慢性活动性损害。EBV特异性抗体检测是最常用的实验室诊断方法。EBV性脑炎目前尚无特效疗法,主要以综合治疗为主,包括抗病毒治疗、对症治疗。虽然EBV性脑炎通常被认为是一种良性自限性疾病,但一部分病例仍可留下后遗症。

For the children,viral encephalitis is a common infectious disease in central nervous system.Epstein-Barr Virus（EBV） is one of the common pathogens.When the EBV invaded the central nervous system,cerebral edema and cerebral bleeding will appear,together with the depositing of the immune compounds and demyelinating of the brain.So the disease can be a sudden onset or a chronic duration.For the laboratory,the special antibody detection of EBV is quite often used.There have no effective treatment till now.Comprehensive therapy play an important role,that is,anti-virus treatment and symptomatic treatment.Usually speaking,the prognosis of EBV encephalitis is benign can be recovered itself,but sequelaes still remained in some cases.